Iodinated Derivatives of Adrenocorticotropic Hormone
نویسندگان
چکیده
منابع مشابه
Iodinated Derivatives of Adrenocorticotropic Hormone PREPARATION OF IODINATED ~x’-~~-ACTH WITH FULL HORMONAL ACTIVITY*
Iodinated derivatives of adrenocorticotropic hormone (ACTH) were prepared with the use of NaI and chloramine-T and isolated by isoelectric focusing. The monoiodinated derivative (p1 7.6) was resolved into [monoiodoTyr2]ACTH and [monoiodoTyrZ3]ACTH by chromatography on columns of carboxymethylcellulose. Both monoiodo-AC’IH species exhibited only 30% of the maximum hormonal activity when assayed ...
متن کاملAdrenocorticotropic action of antidiuretic hormone.
By means of direct arterial perfusion of the adrenal glands of the hypophysectomized dog, it has been shown that synthetic lysine, arginine and acetyl arginine vasopressins stimulate the adrenal cortex directly to secrete hydrocortisone. Pressor activity and cortisol-stimulating activity were demonstrated to be independent of each other. Similar polypeptides, such as oxytocin, insulin, glucagon...
متن کاملAdrenocorticotropic Action of Antidiuretic Hormone
By means of direct arterial perfusion of the adrenal glands of the hypophysectomized dog, it has been shown that synthetic lysine, arginine and acetyl arginine vasopressins stimulate the adrenal cortex directly to secrete hydrocortisone. Pressor activity and cortisol-stimulating activity were demonstrated to be independent of each other. Similar polypeptides, such as oxytocin, insulin, glucagon...
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A priori one would anticipate that the effects of a hormone would be most apparent when given to an individual lacking that hormone. To be sure, when the hormone acts through another gland, as does adrenocorticotropic hormone (ACTH), one might find the "target" gland unresponsive through atrophy. In panhypopituitarism, one is dealing not with a single deficiency, but with a deficiency of all "t...
متن کاملComparison of two automated adrenocorticotropic hormone assays.
The measurement of adrenocorticotropic hormone (ACTH 1-39; Mr 4500) plays a key role in the evaluation of hyperand hypocortisolism (1–3), but low ACTH concentrations make accurate measurement challenging. Two automated, nonisotopic ACTH assays have become available in recent years. Because it is usual for rather small series to be assayed for ACTH in a clinical setting and because nonisotopic m...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)79776-0